Nephroprotective Effect of Aqueous Extract of Pimpinella anisum in Gentamicin Induced Nephrotoxicity in Wistar Rats

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Protective effect of crocin on gentamicin-induced nephrotoxicity in rats

Objective(s): Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. Materials and Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without c...

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Effect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats

Objective(s):Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. Materials and Methods: Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day...

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Protective effects of aqueous extract of M. Pruriens Linn. (DC) seed against gentamicin induced oxidative stress and nephrotoxicity in rats

In the present study, we investigated the effects of the aqueous extract of Mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. Administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. There was a significant decr...

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Nephroprotective Effect of Echinodorus macrophyllus Micheli on Gentamicin-Induced Nephrotoxicity in Rats

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ژورنال

عنوان ژورنال: Pharmacognosy Journal

سال: 2018

ISSN: 0975-3575

DOI: 10.5530/pj.2018.3.66